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nilotinib will enhance the amount or outcome of propafenone by influencing hepatic/intestinal enzyme CYP3A4 metabolism.nilotinib will raise the amount or impact of tucatinib by Other (see comment). Prevent or Use Alternate Drug. Coadministration of tucatinib (a CYP2C8 substrate) with a strong or moderate CYP2C8 inhibitors will increase tucatinib pl